The Pinkerton Research Group is interested in developing responsive soft materials for bioapplications ranging from controlled drug delivery, to vaccines to medical imaging. Taking an interdisciplinary approach, we use tools from chemical and materials engineering, nanotechnology, chemistry and biology to create soft materials via scalable synthetic processes. We focus on understanding how process parameters control the final material properties, and in turn, how the material behaves in biological systems.
Education
Work Experience
Pfizer Oncology
Senior Scientist
2016-2019
L'Institut des Technologies Avancées en Sciences du Vivant (ITAV)
CNRS Postdoctoral Fellow
2014-2016
Publications
1. “Simple and Inexpensive Synthesis of Heterobifunctional Poly(Lactic Acid)-b-Poly(Ethylene Glycol) for Targeted Drug Delivery Applications” R.F. Pagels, N.M. Pinkerton, A.W. York, R.K. Prud’homme, Macromolecular Chemistry and Physics, accepted, 2019.
2. “Quench Ionic Flash Nanoprecipitation (qiFNP) as a Simple and Tunable Approach to Decouple Growth and Functionalization for the One-Step Synthesis of Functional LnPO4-Based Nanoparticles in Water” N.M. Pinkerton, K. Hadri, B. Amouroux, L. Behar, C. Mingotaud, M. Destarac, I. Kulai, S. Mazières, S. Chassaing, J.D. Marty, Chemical Communications, 2018, 54, 9438-9441.
3. “Photochemistry of ortho-Azidocinnamoyl Derivatives: Facile and Modular Synthesis of 2-Acylated Indoles and 2-Substituted Quinolines under Solvent Control” N.M. Pinkerton, S. Chaabouni, S. Abid, C. Galaup, S. Chassaing, Synlett, 2017, 19, 2614-2618.
4. “Ionic Flash NanoPrecipitation for the Facile One-Step Synthesis of Inorganic-Organic Hybrid Nanoparticles in Water” N.M. Pinkerton, L. Behar, B. Amouroux, K. Hadri, C. Mingotaud, D.R. Talham, S. Chassaing, J.D. Marty, Nanoscale, 2017, 4, 1403-1408.
5. “Red-emitting EtTP-5-based organic nanoprobes for two-photon imaging in 3D multicellular biological models” N.M. Pinkerton, C. Frongia, V. Lobjois, B.K. Wilson, M.J. Bruzek, R.K. Prud’homme, J. Anthony, F. Bolze, S. Chassaing, RSC Advances, 2016, 6, 65770-65774.
6. “Single-step assembly of multimodal imaging nanocarriers: MRI and long-wavelength fluorescence imaging” N.M. Pinkerton, M.E. Gindy, V.L. Calero-DdelC, R.F. Pagels, D. Adler, D. Gao, S. Li, M. Zevon, N. Yao, C. Pacheco, M.J. Therien, C. Rinaldi, P.J. Sinko, R.K. Prud’homme, Advanced Healthcare Materials, 2015, 4, 1376-1385.
7. “Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery” N.M. Pinkerton, S.W. Zhang, R.L. Youngblood, D. Gao, S. Li, J. Anthony, H.A. Stone, P.J. Sinko, R.K. Prud’homme, Biomacromolecules, 2014, 15, 252-261.
8. “Formation of stable nanocarriers by in situ ion pairing during block-copolymer-directed rapid precipitation” N.M. Pinkerton, A. Grandeury, A. Fisch, J. Brozio, B.U. Riebesehl, R.K. Prud’homme, Molecular Pharmaceutics, 2013, 10, 319-328.
9. “Initiated chemical vapor deposition (iCVD) of conformal polymeric nanocoatings for the surface modification of high aspect ratio pores” M. Gupta, V. Kapur, N.M. Pinkerton, and K.K. Gleason, Chemistry of Materials, 2008, 20, 1646-1651.
10. “1,5-Asymmetric induction during nucleophile additions to arenechromium tricarbonyl complexes, η6-{4-[[Spiro[(1R,2S)- 1,7,7-trimethylbicyclo[2.2.1]heptane-3.2'-[1,3]dioxolan]-2-yl]oxy]toluene}chromium tricarbonyl” H. Paramahamsan, A.J. Pearson, N.M. Pinkerton and A.A. Pinkerton, Acta Crystallographica Section C, 2008, 64, m147-m148.
Patents
1. “Encapsulation of hydrophilic actives into nanocarriers via hydrophobic ion-pairing” Patent Application US 62581394: R.K. Prud’homme, K.D. Ristroph, N.M. Pinkerton, H.D. Lu, 2018.
2. “Lung targeting dual drug delivery system” Patent Number US 9421194: R.K. Prud’homme, P.J. Sinko, H.A. Stone, N.M. Pinkerton, L. Shi, J. Wan, S. Ibrahim, D. Gao, 2016.
Research Centers, Labs, and Groups
Pinkerton Research Group
Focuses on developing responsive soft materials for biomedical applications. The group uses ...
